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US 4,927,947 AGranted
Ethynylheteroaromatic-acids having retinoic acid-like activity
AssigneeAllergan, Inc.
InventorRoshantha A. S. Chandraratna
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Abstract
Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH and its esters, amides and pharmaceutically acceptable salts, --CHO and its acetal derivatives, --COR.sub.1 and its ketal derivatives where R.sub.1 is --(CH.sub.2).sub.n CH.sub.3 where n is defined above, or --CH.sub.2 OH and its ether and acyl ester derivatives; or a pharmaceutically acceptable salt.
Claims3
A compound of the formula ##STR6## where A is furyl;
- n is 0-5;
- and
- B is H, --COOH or its esters, amides and pharmaceutically acceptable salts, --CHO and its acetal derivatives, --CH.sub.2 OH and its ether and acyl ester derivatives, or --COR.sub.1 and its ketal derivatives where R.sub.1 is --(CH.sub.2).sub.n CH.sub.3 where n is defined above;
- or a pharmaceutically acceptable salt.
1 more element
Dependencies are inferred from the claim text.