Acylphenol derivatives, useful as anti-inflammatory agents and pain suppressants

A pharmaceutical composition useful for effecting analgesic, anti-inflammatory, and anti-pyretic action in humans and animals which comprises a therapeutically effective amount of a compound of the formula ##STR14## or a pharmaceutically acceptable salt thereof, wherein:

• R.sup.1 is ##STR15## wherein A is sulfur, and R.sup.6 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo;
• R.sup.2 is straight or branched chain alkyl of 1 to 4 carbon atoms or cycloalkyl of 5 to 7 carbon atoms;
• and
• R.sup.3 and R.sup.4 are the same or different and each is hydrogen;
• straight or branched chain alkyl of 1 to 8 carbon atoms unsubstituted or substituted by hydroxy, acyloxy of 2 to 5 carbon atoms, carboxyl or carbamoyl;
• straight or branched chain alkenyl of 2 to 6 carbon atoms;
• straight or branched chain alkynyl of 2 to 6 carbon atoms;
• or cycloalkyl of 5 to 7 carbon atoms, in combination with a pharmaceutically acceptable carrier.

A method of treating pain, inflammation and fever in humans and animals, which comprises administering to a human or animal in need thereof a therapeutically effective amount of a compound of the formula ##STR16## or a pharmaceutically acceptable salt thereof, wherein:

• R.sup.1 is ##STR17## wherein A is sulfur, and R.sup.6 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo;
• R.sup.2 is straight or branched chain alkyl of 1 to 4 carbon atoms or cycloalkyl of 5 to 7 carbon atoms;
• and R.sup.3 and R.sup.4 are the same or different and each is hydrogen;
• straight or branched chain alkyl of 1 to 8 carbon atoms unsubstituted or substituted by hydroxy, acyloxy of 2 to 5 carbon atoms, carboxyl or carbamoyl;
• straight or branched chain alkenyl of 2 to 6 carbon atoms;
• straight or branched chain alkynyl of 2 to 6 carbon atoms;
• or cycloalkyl of 5 to 7 carbon atoms, in combination with a pharmaceutically acceptable carrier.