Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same
Assignee501 Kabushiki Kaisha Hayashibara Kagaku Kenkyujo
InventorsHiromi Hijiya, Toshio Miyake
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Abstract
Pullulan forms an association complex with PEG in a hydrous system. The assocation complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association reduces or even eliminates the excessively high water-solubility, threading and stickiness of pullulan so that this extends the uses of pullulan and PEG such as those in gradually disintegrable- and sustained release-shaped articles for consumer's products, toiletries, cosmetics, pharmaceuticals and feeds.
Claims13
A complex, comprising pullulan and polyethylene glycol associated on a molecular level via hydrogen bonds and having a decreased water solubility with respect to the water solubility of said pullulan and said polyethylene glycol, said polyethylene glycol having a molecular weight in the range of about 200-10,000, and wherein the amount of polyethylene glycol is in the range of 0.01-100 parts by weight with respect to one part by weight of pullulan, based on the dry solid.
A process for preparing a complex comprising pullulan and polyethylene glycol associated on a molecular level via hydrogen bonds and having a decreased water-solubility with respect to pullulan and the polyethylene glycol, said process comprising:
- contacting pullulan with the polyethylene glycol in a hydrous system to effect association wherein the amount of the polyethylene glycol is in the range of 0.01-100 parts by weight with respect to one part by weight of pullulan, based on the dry solid, and the molecular weight of the polyethylene glycol is in the range of about 200-10,000;
- and
- recovering the resultant complex.
A process for preparing a composition, said process comprising the step of mixing
- (1) a complex comprising pullulan and polyethylene glycol associated on a molecular level via hydrogen bonds and having decreased water-solubility with respect to pullulan and said polyethylene glycol wherein the amount of the polyethylene glycol is in the range of 0.01-100 parts by weight with respect to one part by weight of pullulan, based on the dry solid, and the molecular weight of the polyethylene glycol is in the range of about 200-10,000, and
- (2) at least one additional substance selected from the the following an antibacterial agent, an insecticide, a coloring agent, a flavoring agent, a nutrient, a bioactive substance, a medicament, an inclusion compound with cyclodextrin, a plasticizer, a filler, a foaming agent, a vehicle and a flame retarder.
Dependencies are inferred from the claim text.