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US 4,927,408 AGranted
Electrotransport transdermal system
AssigneeAlza Corporation
InventorsRonald P. Haak, Felix Theeuwes, J. Richard Gyory
Life of this patent
Estimating the term…
Abstract
A transdermal therapeutic system which utilizes electrical current to facilitate agent delivery and which isolates the electrochemical reactants and products from the agent containing reservoir.
Claims21
An electrotransport system for placement on a body surface and delivering an agent through said surface, the system comprising:
- a non-conductive backing member;
- a source of electrical power comprising first and second current conducting members, said current conducting members being positioned adjacent to said backing member;
- a first electrode pad comprising a first reservoir containing an electrolyte and a second reservoir containing the agent, said electrolyte-containing reservoir, positioned adjacent to said first current conducting member and said agent-containing reservoir adapted to be positioned in current conducting relationship to said body surface;
- a selectively permeable membrane separating the first and second reservoirs from one another, the membrane comprising a microporous polymer which is impermeable to the agent and to chemical species having a molecular weight greater than a predetermined molecular weight and permeable to chemical species having a molecular weight less than the predetermined molecular weight;
- a second electrode pad positioned adjacent to said second current conducting member and adapted to be positioned in current conducting relationship to said body surface;
- an insulating means electrically insulating said first and said second electrode pads from each other;
- and
- a means for maintaining said system in current conducting and agent transmitting relationship to said body surface.
5 more elements
A self contained electrotransport transdermal system for placement on a body surface and delivering an agent through said surface, the system comprising:
- a non-conductive backing member;
- a source of electrical power comprising first and second current conducting members, said current conducting members being positioned adjacent to said backing member, said first current conducting member being composed at least in part of an oxidizable metal;
- a first electrode pad comprising a first reservoir containing an electrolyte and a second reservoir containing the agent, said electrolyte-containing reservoir positioned adjacent to said first current conducting member and said agent-containing reservoir adapted to be positioned in current conducting relationship to said body surface;
- a selectively permeable membrane separating the first and second reservoirs from one another, the membrane comprising a hydrogel material which is loaded with a chelating agent, the loaded hydrogel material being capable of trapping metal ions produced by the oxidation of the metal in the first current conducting member;
- a second electrode pad positioned adjacent to said second current conducting member and adapted to be positioned in current conducting relationship to said body surface;
- an insulating means electrically insulating said first and said second electrode pads from each other;
- and
- a means for maintaining said system in current conducting and agent transmitting relationship to said body surface.
5 more elements
Dependencies are inferred from the claim text.