Back to results
US 4,925,968 AGranted
N-acyl-N-naphthoylglycines as aldose reductase inhibitors
AssigneeAmerican Home Products Corporation
InventorsKazimir Sestanj, Jay E. Wrobel, Joseph M. Kelly
Life of this patent
Estimating the term…
Abstract
Disclosed herein are N-acyl-N-naphthoylglycines and methods of their preparation. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
Claims1
The chemical intermediate compounds of formula (VII) ##STR18## wherein R is hydrogen, lower alkyl containing 1 to 3 carbon atoms, lower alkoxy containing 1 to 6 carbon atoms, trifluoroethoxy, phenyl, benzyloxy, chloro- and nitro-substituted benzyloxy, or lower dialkylamino containing 1 to 3 carbon atoms;
- R.sup.1 is hydrogen or lower alkoxy containing 1 to 3 carbon atoms and R.sup.2 is halogen or lower perfluoroalkyl containing 1 to 3 carbon atoms.
Dependencies are inferred from the claim text.