6-thioxanthines
AssigneeEuroceltique, S.A.
InventorPeter Hofer
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Abstract
A 6-thioxanthine of general formula I or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.3 is a C.sub.2 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group and R.sub.8 is a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group provided that when R.sub.3 is an ethyl, n-propyl or n-butyl group, R.sub.8 is a C.sub.3 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group. These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity.
Claims11
A compound selected from the group consisting of 3-(2-methylbutyl)-8-ethyl-6-thioxanthine, 3-ethyl-8-n-butyl-6-thioxanthine, 3-n-propyl-8-n-butyl-6-thioxanthine, 3-n-propyl-8-n-pentyl-6-thioxanthine, 3-n-propyl-8-cyclopropyl-6-thioxanthine, 3-n-propyl-8-cyclobutyl-6-thioxanthine 3-isobutyl-8-n-butyl-6-thioxanthine 3-n-pentyl-8-ethyl-6-thioxanthine and 3-isopentyl-8-ethyl-6-thioxanthine, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.