Endothelial envelopment drug carriers

A composition comprising a drug carrier or diagnostic-carrier combination which contains a drug or diagnostic agent of amphotericin B entrapped in a controlled-release form within internal micelles of a polyoxyethylene-polyoxypropylene block copolymer including PLURONIC F68, and includes a multivalent binding agent surface coating specific for determinants of endothelial or epithelial cells;

• wherein the drug-carrier or diagnostic carrier combination comprises a microsphere or microaggregate between 3 nanometers and 200 micrometers in diameter, and having a matrix which contains the drug of diagnostic agent at a content of about 12-30% (w/w);
• and
• wherein the multivalent binding agent consists essentially of carbohydrate, oligosaccharide, negatively charged polysaccharide, or negatively charged oligosaccharide, which induces rapid partial or total envelopment of said combination by endothelial or epithelial cells and facilitated migration across said cells to proximal tissues.

A composition comprising a drug-carrier or diagnostic-carrier combination which contains a drug or diagnostic agent of amphotericin B at a content of at least about 14% (w/w) in a controlled-release form within internally entrapped adducts of gamma cyclodextrin, and includes a multivalent binding agent surface coating specific for determinants of endothelial or epithelial cells;

• wherein the drug-carrier or diagnostic carrier combination comprises a microsphere or microaggregate between 3 nanometers and 200 micrometers in diameter, and has a dextran matrix which contains the drug or diagnostic agent;
• and
• wherein the multivalent binding agent is heparin at a content of about 10% (w/w) which induces rapid partial or total envelopment of said combination by endothelial or epithelial cells and facilitated migration across said cells to proximal tissues.

A composition comprising a drug-carrier or diagnostic-carrier combination which contains a drug or diagnostic agent of amphotericin B in a controlled-release form within internally entrapped micelles of a PLURONIC block copolymer polyoxyethylene-polyoxypropylene including PLURONIC F68, and includes a multivalent binding agent surface coating specific for determinants of endothelial or epithelial cells;

• wherein the drug-carrier or diagnostic carrier combination comprises a microsphere or microaggregate between 3 nanometers and 200 micrometers in diameter, and has a dextran matrix which contains the drug or diagnostic agent at a content of about 12-30% (w/w);
• and
• wherein the multivalent binding agent is heparin at a content of about 10% (w/w) and induces rapid partial or total envelopment of said combination by endothelial or epithelial cells and facilitated migration across said cells to proximal tissues.