Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
AssigneeTheratech, Inc.
InventorJan Feijen
Life of this patent
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Abstract
A biodegradable hydrogen matrix is provided, useful for the controlled release of pharmacologically active agents. The matrix is formed by cross-linking a proteinaceous component and a polysaccharide or mucopolysaccharide, and then loading a selected drug therein. By varying temperature, ionic strength, and the composition of the hydrogel matrix, one can control degradation kinetics, the degree of uptake of a particular pharmacologically active agent, and the overall timed release profile.
Claims31
A drug delivery system comprising:
- (a) a biodegradable endogenous hydrogel matrix comprising a protein, a polysaccharide, and a cross-linking agent providing network linkage therebetween, wherein the weight ratio of polysaccharide to protein in the matrix is in the range of about 10:90 to 90:10;
- and
- (b) an effective amount of a drug contained within the matrix to provide the desired systemic or local effect.
A method for making a drug delivery system, comprising:
- dissolving a protein and a polysaccharide in an aqueous medium wherein the weight ratio of polysaccharide to protein is in the range of 10:90 to 90:10;
- cross-linking the protein and polysaccharide to provide a cross-linked hydrogel matrix;
- and
- loading an effective amount of a drug in solution or in liquid form into said hydrogel matrix to a predetermined degree wherein the cross-linking is effected by admixture of the protein and polysaccharide components with a cross-linking agent.
A method of administering a drug to a patient so that release of the drug is controlled, comprising the steps of administering the drug in a biodegradable hydrogel matrix which comprises a protein, a polysaccharide, and a cross-linking agent providing network linkage therebetween, wherein the weight ratio of polysaccharide to protein is in the range of about 10:90 to 90:10.
Dependencies are inferred from the claim text.