Oral vaccines
AssigneeAmerican Home Products Corporation
InventorsAlan R. Davis, Paul P. Hung
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Abstract
Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.
Claims1
A recombinant adenovirus containing a gene coding for an antigen produced by a disease-causing organism said recombinant adenovirus being of type 7;
- the gene codes for hepatitis-B surface antigen;
- and the gene is located at delected early region 3;
- said recombinant adenovirus being ATCC VR2167.
Dependencies are inferred from the claim text.