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US 4,920,203 AGranted
Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
AssigneeAllied-Signal Inc.
InventorsReginald T. Tang, Frank Mares, William J. Boyle, Jr., Tin-Ho Chiu, Kundabhai M. Patel
Life of this patent
Estimating the term…
Abstract
This invention relates to medical devices formed totally or in part from homopolymers or copolymers comprising recurring carbonate moieties.
Claims38
A medical device formed totally or in part of one or more biopolymers selected from the group consisting of block copolymers having at least one type of recurring monomeric unit of the following General Structures I and II:
- ##STR12## wherein:
- Z is --C(R.sub.5 R.sub.6)--, --NR.sub.5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms;
- n is from 1 to about 8;
- m is from 1 to about 8;
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more substituents selected from the group consisting of alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino, and alkylarylamino;
- and
- R.sub.5 and R.sub.6 are the same or different and are R.sub.1, R.sub.2, R.sub.3, R.sub.4, dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R.sub.1 to R.sub.6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups;
- with the proviso that when said biopolymers are copolymer having recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of the copolymer are not derived from gylcolide or glycolic acid.
5 more elements
A block copolymer comprising at least one type of recurring monomeric unit of the following General Structures I and II:
- ##STR15## wherein:
- Z is --C(R.sub.5 R.sub.6)--, --NR.sub.5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms;
- n is from 1 to about 8;
- m is from 1 to about 8;
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more biologically compatible substituents;
- and
- R.sub.5 and R.sub.6 are the same or different and are R.sub.1, R.sub.2, R.sub.3, R.sub.4, dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R.sub.1 to R.sub.6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups;
- with the proviso that when said copolymers have recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of copolymer are not derived from gylcolide or glycolic acid.
5 more elements
Dependencies are inferred from the claim text.