Lipid vesicles formed of surfactants and steroids
AssigneeMicro-Pak, Inc.
InventorDonald F. H. Wallach
Life of this patent
Estimating the term…
Abstract
Disclosed is a method of making lipid vesicles of a steroid and surfactants which do not form vesicles in the absence of the steroid. The surfactants are polyoxyethylene derivatives of 16-20 carbon ethers and amines.
Claims8
A multilamellar lipid vesicle formed of surfactant materials which do not form vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of:
- polyoxyethylene (n) cetyl ethers where n ranges from 5-10;
- polyoxyethylene (x) stearyl ethers where x ranges from 2-10;
- polyoxyethylene (y) oleyl ethers where y ranges from 2-10;
- polyoxyethylene (z) linoleyl ethers where z ranges from 2-10;
- polyoxyethylene (s) eicosamonoenoyl ethers where s ranges from 2-10;
- polyoxyethylene (t) eicosadienoyl ethers where t ranges from 2-10;
- and
- about 20-50% of a steroid.
A multilamellar lipid vesicle formed of surfactant materials which do not form these vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of:
- polyoxyethylene (n') cetyl amines where n' ranges from 5-10;
- polyoxyethylene (x') stearyl amines where x' ranges from 5-10;
- polyoxyethylene (y') oleyl amines where y' ranges from 5-10;
- polyoxyethylene (z') linoleyl amines where z' ranges from 5-10;
- polyoxyethylene (s') eicosamonoenoyl amines where s' ranges from 5-10;
- polyoxyethylene (t') eicosadienoyl amines where t' ranges from 5-10;
- and
- about 20-50% of a steroid.
Dependencies are inferred from the claim text.