Processes for preparation of aloe products, products produced thereby and compositions thereof
AssigneeCarrington Laboratories, Inc.
InventorBill H. McAnalley
Life of this patent
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Abstract
Processes for producing aloe extracts including the separation of the leaves of the aloe plant into distinct portions. In particular, a first process is described for producing an aloe extract which is substantially free of anthraquinone-rich yellow sap and a second process is described for extracting the active chemical substance in the aloe plant. The active chemical substance in the aloe plant is extracted from aloe leaves and its characteristic properties are described.
Claims63
A process for producing a substantially anthraquinone-free aloe gel from a leaf of the aloe plant, comprising:
- (a) washing an aloe leaf in a bacteriacidal solution to remove substantially all surface dirt and bacteria;
- (b) removing at least a first end portion from said washed leaf;
- (c) draining, preserving and collecting anthraquinone rich sap from said cut and washed leaf;
- and
- (d) removing rind from said leaf to produce a substantially anthraquinone free gel.
A process for producing substantially anthraquinone-free aloe gel from a leaf of the aloe plant, comprising:
- (a) crushing a leaf of an aloe plant;
- and
- (b) dialyzing the crushed leaf chemically to remove and separate a substantially anthraquinone-free aloe gel from remaining fractions of the crushed leaf.
A process for producing substantially anthraquinone-free juice from a leaf of the aloe plant comprising:
- (a) washing an aloe leaf in a bacteriacidal solution substantially to remove surface dirt and bacteria;
- (b) removing a first end portion and a second end portion from said washed leaf;
- (c) draining, preserving and collecting anthraquinone rich sap from said washed and cut leaf;
- (d) removing rind from said leaf to produce a substantially anthraquinone-free aloe gel fillet;
- and
- (e) grinding and homogenizing said substantially anthraquinone-free aloe gel fillet to produce substantially anthraquinone-free aloe juice.
A process for extracting the active chemical substance in the aloe plant from a leaf of the aloe plant, comprising steps of:
- (a) obtaining aloe juice having solubilized matter;
- (b) adding a water soluble, lower aliphatic polar solvent to the aloe juice to precipitate the active chemical substance and thereby to form a heterogeneous solution;
- (c) removing the water soluble, lower aliphatic polar solvent and the solubilized matter from the heterogeneous solution to isolate the precipitated active chemical substance;
- and
- (d) drying the precipitated active chemical substance.
A composition of matter for a topical wound gel, comprising:
- (a) 0.1 to 100 wt. % substantially anthraquinone-free aloe juice,
- (b) 0 to 2 wt. % allantoin,
- (c) 0 to 6 wt. % panthenol,
- (d) one or more excipients or carriers.
A composition of matter for drinking, comprising:
- (a) 0.1 to 100 wt % substantially anthraquinone-free aloe juice,
- (b) a food preservative
- (c) citric acid;
- and
- (d) vitamin E.
A base formulation for the production of Aloe vera containing topical products, comprising:
- (a) one or more preservatives;
- and
- (b) a substantially anthraquinone-free aloe juice.
A base formulation for the production of Aloe vera containing topical products, comprising:
- (a) methylparaben;
- (b) potassium sorbate;
- and
- (c) a substantially anthraquinone-free aloe juice,
- wherein the weight ratio of methylparaben to potassium sorbate is about 1.79:1.
A moisture-resistant ointment emulsion formulation for topical administration, having an aqueous component phase and an oil component phase, comprising:
- (A) for the aqueous phase:
- (1) a substantially anthraquinone-free aloe juice;
- (2) an agent to reduce skin surface tension and to permit adsorption on the skin of said aloe juice;
- (3) an active agent to promote healing of the skin;
- (4) one or more preservatives for the water phase;
- and a
- (5) pH adjuster for the aqueous phase;
- and
- (B) for the oil phase:
- (1) one or more oil barrier agents to prevent the removal of the aqueous phase from the skin by contact of the skin by an aqueous-containing solution;
- (2) one or more thickness for the oil phase;
- (3) a mixing agent for the oil phase;
- (4) a skin softener;
- (5) an oil base for the oil phase;
- and
- (6) a preservative.
A moisture-resistant emulsion formulation for topical administration having an aqueous component phase and an oil component phase, comprising:
- (A) for the aqueous phase:
- (1) a substantially anthraquinone-free aloe juice;
- (2) propylene glycol;
- (3) allantoin;
- (4) methylparaben;
- (5) imidazolidinyl urea;
- (6) sorbitol;
- and
- (7) phosphoric acid;
- and
- (B) for the oil phase:
- (1) glyceryl sterate;
- (2) stearyl stearate;
- (3) dioctyl adipate and octyl sterate and octyl palmitate;
- (4) palmitamidopropyl dimethylamine;
- (5) cetyl alcohol;
- (6) lanolin;
- (7) mineral oil;
- (8) dimethicone;
- and
- (9) propylparaben,
- wherein:
- (1) in the aqueous phase, the weight ratio of propylene glycol to allantoin to methylparaben to imidazolidinyl urea to sorbitol to phosphoric acid is 17:1:0.75:0.002:1:l;
- and
- (2) in the oil phase, the weight ratio of glyceryl stearate to stearyl stearate to dioctyl adipate and octyl stearate and octyl palmitate to palmitamidopropyl dimethylamine to cetyl alcohol to lanolin to mineral oil to dimethicone to propylparaben is about 36:9:9:3.5:3.5:3.5:3.5:1:0.3.
An aloe-based counter-irritant formulation having a water phase and an oil phase for treatment of soft-tissue skin injury, comprising:
- (A) A carrier slurry for the water phase, comprising a water-miscible thickener;
- (B) A water phase, comprising:
- (1) a substantially anthraquinone-free aloe juice;
- (2) an agent to reduce surface tension and to permit adsorption on the skin of the aloe juice;
- (3) a surfactant-emulsifier and pH adjuster;
- (4) an active agent to promote healing of the skin;
- (5) a thickener for the water phase;
- and
- (6) one or more preservatives;
- (C) An oil phase, comprising:
- (1) an extended wear vehicle for an oil base;
- (2) an oil base;
- (3) one or more thickeners for the oil phase;
- (4) a mixing agent;
- (5) one or more active counter-irritant agents;
- (6) one or more preservatives;
- and
- (7) an anti-inflammatory agent.
An aloe-based counter-irritant formulation having a water phase and an oil phase for treatment of soft-tissue skin injury, comprising:
- (A) A carrier slurry for the water phase, comprising one or more cross-linked, high molecular acrylic acid polymers;
- (B) A water phase, comprising:
- (1) a substantially anthraquinone-free aloe juice;
- (2) propylene glycol;
- (3) triethanolamine;
- (4) allantoin;
- (5) methylparaben;
- (6) potassium sorbate and urea;
- (C) An oil phase, comprising:
- (1) petroleum USP (white);
- (2) Carnation (white) mineral oil;
- (3) mineral oil;
- (4) lanolin alcohol;
- (5) acetylated lanolin alcohol;
- (6) stearic acid;
- (7) glyceryl stearate;
- (8) dioctyl adipate;
- (9) octyl stearate;
- (10) octyl palmitate;
- (11) white oleic acid;
- (12) stearyl stearate;
- (13) propylparaben;
- (14) butylparaben;
- (15) cetyl alcohol;
- (16) eucalyptus oil;
- (17) methylsalicylate;
- (18) camphor;
- (19) menthol;
- and
- (20) histamine dihydrochloride
- wherein the ratio of acrylic acid polymer to propylene glycol to triethanolamine to allantoin to methylparaben to potassium sorbate to urea to petroleum USP (white) to Carnation (white) mineral oil to mineral oil and lanolin alcohol to acetylated lanolin alcohol to stearic acid to glyceryl stearate to dioctyl adipate and octyl stearate and octyl palmitate to white oleic acid to stearyl stearate to propylparaben to butylparaben to cetyl alcohol to eucalyptus oil to methylsalicylate to camphor to menthol to histamine dihydrochloride is about 4:49.5:8.9:0.59:1:0.5:19.8:7.5:6.9:6.9:21.4:9.4:9.4:1:1:1:1:7.5:19.8:0.123 :19.8:19.8:0.5.
A composition of matter for a topical wound gel, comprising:
- (a) 0.1% up to about 100 wt. % substantially anthraquinone-free aloe juice;
- (b) less than 2 wt. % allantoin;
- (c) less than 6 wt. % panthenol;
- (d) a water-miscible thickener;
- (e) a nutrient;
- (f) one or more surfactant-emulsifiers and pH adjusters;
- and
- (g) one or more preservatives.
A composition of matter for a topical wound gel, comprising:
- (a) a water-soluble, hydrophilic aliphatic polymer resin consisting of cross-linked, high-molecular weight acrylic acid polymers;
- (b) a substantially anthraquinone-free aloe juice;
- (c) panthenol;
- (d) allantoin;
- (e) L-glutamic acid;
- (f) imidazolidinyl urea, potassium sorbate and sodium benzoate;
- and
- (g) triethanolamine.
A composition of matter for a topical wound gel, comprising:
- (a) a water-soluble, hydrophilic aliphatic polymer resin consisting of cross-linked, high-molecular weight acrylic acid polymers;
- (b) a substantially anthraquinone-free aloe juice;
- (c) panthenol;
- (d) allantoin;
- (e) L-glutamic acid;
- (f) imidazolidinyl urea, potassium sorbate and sodium benzoate;
- and
- (g) triethanolamine,
- wherein the weight ratio of the hydrophilic aliphatic polymer to the substantially anthraquinone-free aloe juice to the panthenol to the allantoin to the L-glutamic acid to the imidazolidinyl urea to the potassium sorbate to the sodium benzoate to the triethanolamine is approximately 0.7:95.45:
- 2.0:0.6:0.3:0.1:0.05:0.1:0.7.
A composition of matter for drinking, comprising:
- (a) less than 100 wt. % substantially anthraquinone-free aloe juice;
- (b) sodium benzoate and potassium sorbate;
- (c) citric acid;
- (d) Vitamin E;
- (e) glycine;
- (f) vanilla;
- and
- (g) cinnamon oil.
A composition of matter for drinking, comprising:
- (a) less than 100 wt. % substantially anthraquinone-free aloe juice;
- (b) sodium benzoate and potassium sorbate;
- (c) citric acid;
- (d) Vitamin E;
- (e) glycine;
- (f) vanilla;
- and
- (g) cinnamon oil,
- wherein the weight ratio of substantially anthraquinone-free aloe juice to sodium benzoate to potassium sorbate to citric acid to Vitamin E to glycine to vanilla to the cinnamon oil is approximately 989.011:0.986:0.493:1.085:0.261:7.829:0.316:0.019.
Dependencies are inferred from the claim text.