Back to results
US 4,914,210 AGranted
Oligonucleotide functionalizing reagents
AssigneeCetus Corporation
InventorsCorey Levenson, Chu-An Chang, Fred T. Oakes
Life of this patent
Estimating the term…
Abstract
Oligonucleotide functionalizing reagents are disclosed which are useful in introducing sulfhydryl, amino and additional hydroxyl groups into oligonucleotides. The reagents are substantially linear in structure, at one end provided with a phosphoramidite moiety, at an opposing end provided with a sulfhydryl, amino or hydroxyl moiety, the two ends linked through a hydrophilic spacer chain. Methods of using and synthesizing the novel reagents are disclosed as well.
Claims7
An oligonucleotide functionalizing reagent having the structure:
- ##STR34## wherein R is a protected amino, sulfhydryl, or hydroxyl moiety;
- R.sup.1 is a protected hydroxymethyl or hydrogen;
- R.sup.2 is methyl or .beta.-cyanoethyl,
- R.sup.3 is lower alkyl;
- and
- N is an integer in the range of 2 through 20 inclusive.
3 more elements
Dependencies are inferred from the claim text.