Tissue adhesive
AssigneeImmuno Aktiengesellschaft fur chemisch-medizinische Produkte
InventorThomas Seelich
Life of this patent
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Abstract
A tissue adhesive in lyophilized form contains at least one biologically compatible tenside beside fibrinogen and factor XIII and optionally further proteins as well as adjuvants or additives. The presence of these biologically compatible tensides was found to shorten the reconstitution times of lyophilized tissue adhesive preparations without negatively affecting the biochemical, mechanical or biological properties of the preparation or of the tibrin formed therefrom.
Claims20
In a tissue adhesive for seamlessly or seam-supportingly connecting human or animal tissue or organ parts, for sealing wounds, stopping bleeding and stimulating wound healing in lyophilized form and having a fibrinogen content of at least 0.25 (25% by mass) and a factor XIII content, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen being at least 150, the improvement comprising at least one biologically compatible tenside in addition to fibrinogen.
A method for seamlessly or seamsupportingly connecting human or animal tissue or organ part, for sealing wounds, stopping bleeding and stimulating wound healing comprising the application of a lyophilized composition based on human or animal proteins comprising a fibrinogen content of at least 0.25 (25% by mass) of the dry substance, a factor XIII content in an amount of at least 150 units per gram of fibrinogen, and a content of at least one biologically compatible tenside, the total tenside content being from 0.0003 to 0.15 (0.03 to 15% by mass) of the fibrinogen content, for producing a tissue adhesive solution ready for use at a concentration of at least 70 mg of fibrinogen/ml.
Dependencies are inferred from the claim text.