Monoclonal antibodies to human kininogen and methods of preparing same
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsRobert W. Colman, Alvin H. Schmaier
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Abstract
Two novel cell lines, ATCC #HB-8963 and ATCC #HB-8964 produce monoclonal antibody to human kininogen. One of the antibodies specifically recognizes the heavy chain of high and low molecular weight kininogen (the later protein is identical to alpha cysteine protease inhibitor). The other antibody recognizes the light chain of high molecular weight kininogen. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with P3X63Ag8 or SP2/0-Ag14 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.
Claims15
A monoclonal antibody which specifically binds to an antigenic determinant of human kininogen, which antigenic determinant is characterized by binding to monoclonal antibody produced by hybridoma ATCC #HB-8963 or ATCC #HB-8964.
The cell line ATCC #HB-8963.
The monoclonal antibody produced by the cell line ATCC #Hb-8963.
The cell line ATCC #HB-8964.
The monoclonal antibody produced by the cell line ATCC #HB-8964.
Dependencies are inferred from the claim text.