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US 4,908,389 AGranted
Penetration enhancement system
AssigneeWarner-Lambert Company
InventorsMajid Mahjour, Uma Iyer, Mahdi B. Fawzi
Life of this patent
Estimating the term…
Abstract
The penetration of various drugs through living membranes, eg., skin, is improved by their use in topical compositions containing certain penetration-enhancer systems.
Claims2
A transmembranally administrable composition comprising:
- (a) about 0.2% to about 5% of a bioaffecting agent selected from the group consisting of procaterol, 4,5-dihydro-6-[4-(1H-imidazole-1-yl)phenyl]-5-methyl-3-(2H)-pyridazinone, morphine, hydromorphone, propanolol, chlorpheniramine and a pharmaceutically acceptable organic or inorganic acid,
- (b) about 1% to about 202% of a fatty component selected from the group consisting of linoleic acid, C.sub.1 -C.sub.3 linoleic esters, and a monohydroxy linoleyl alcohol,
- (c) about 80% to about 99% of a secondary component consisting of a mixture of a compound selected from the group consisting of isopropanol, propylene glycol, polyethylene glycol 400 and tetraglycol, and a compound selected from the group consisting of triacetin and triethyl citrate.
A method of administering a bioaffecting agent comprising contacting a transmembranally administrable composition comprising:
- (a) about 0.2% to about 5% of a bioaffecting agent selected from the group consisting of procaterol, 4,5-dihydro-6-[4-(1H-imidazole-1-yl)phenyl]-5-methyl-3-(2H)-pyridazinone, morphine, hydromorphone, propanolol, chlorpheniramine and a pharmaceutically acceptable organic or inorganic acid,
- (b) about 1% to about 20% of a fatty component selected from the group consisting of linoleic acid, C.sub.1 -C.sub.3 linoleic esters, and a monohydroxy linoleyl alcohol,
- (c) about 80% to about 99% of a secondary component consisting of a mixture of a compound selected from the group consisting of isopropanol, propylene glycol, polyethylene glycol 400 and tetraglycol, and a compound selected from the group consisting of triacetin and triethyl citrate with a living membrane.
Dependencies are inferred from the claim text.