.alpha.-halogenated dicarboxylic acids, pharmaceutical compositions and method of use
AssigneeEpis S.A.
InventorsJacob Bar-Tana, Yoelit Migron, Jochanan Blum, Bruno Dreckmann, Johannes Pill
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Abstract
The present invention provides pharmaceutical compositions containing at least one .alpha.-halogenated dicarboxylic acid of the general formula: ##STR1## wherein Hal is a chlorine, bromine or fluorine atom, R is a hydrogen atom or Hal and m is a number of from 4 to 16, and/or at least one pharmacologically acceptable salt, ester or amide thereof. The present invention also provides new compounds of general formula (I) but in which m is a number of from 8 to 16 and processes for the preparation thereof.
Claims11
A pharmaceutical composition comprising (1) an effective amount of at least one alpha-halogenated dicarboxylic acid compound of the formula:
- ##STR4## wherein Hal is chlorine, bromine or fluorine
- R is hydrogen or Hal, and
- m is a number from 4 to 16,
- or at least one pharmaceutically acceptable salt, ester or amide of said compound, and (2) a pharmaceutical carrier.
A method for the treatment of adipositas, hyperlipidaemia or diabetes comprising administering a pharmaceutically effective amount of at least one of the compounds of the formula ##STR5## wherein Hal is chlorine, bromine or fluorine,
- R is hydrogen or Hal, and
- m is a number from 4 to 16,
- or at least one pharmaceutically acceptable salt, ester or amide of said compound to mammals in need of said treatment.
A method for the treatment of adipositas, hyperlipidaemia or diabetes comprising administering a pharmaceutically effective amount of the compound designated 2,2,13,13-tetrachlortetradecane-1,14-dioic acid to mammals in need of said treatment.
An alpha-halogenated dicarboxylic acid compound designated 2,2,13,13-tetrachlortetradecane-1,14-dioic acid.
An alpha-halogenated dicarboxylic acid compound designated 2,15-dichlorohexadecane-1,16-dioic acid.
Dependencies are inferred from the claim text.