2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles in composition form for reducing intraocular pressure
AssigneeCiba-Geigy Corporation
InventorsCharles F. Huebner, John E. Francis
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein each R is hydrogen or one R is hydrogen and the other is lower alkyl, R.sub.1 is hydrogen, lower alkyl, aryl, aralkyl or lower carboalkoxy, R.sub.2 is hydrogen or lower alkyl, and the ring A is unsubstituted or substituted by lower alkyl, lower alkoxy, halo or trifluoromethyl, and pharmaceutically acceptable salts thereof, their preparation, pharmaceutical compositions and the uses thereof, such as .alpha..sub.2 -adrenergic blocking agents, e.g. antidepressants, cognition enhancers and appetite suppressants, and as intraocular pressure reducing agents are disclosed.
Claims1
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and an effective intraocular pressure reducing amount of a compound of the formula ##STR7## wherein each R is hydrogen or one is hydrogen and one is lower alkyl;
- R.sub.2 is hydrogen or lower alkyl;
- and ring A is unsubstituted or substituted by lower alkoxy, and R.sub.1 is hydrogen, methyl, or benzyl;
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.