Anxiolytic-n-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides
AssigneeA. H. Robbins Company, Incorporated
InventorsRobert J. Naylor, Brenda Naylor
Life of this patent
Estimating the term…
Abstract
Compounds of general formula I: ##STR1## wherein: X represents oxygen or sulphur; R.sup.1 represents loweralkyl; R.sup.2 represents hydrogen, halo, 4,5-benzo, loweralkoxy, amino, methylamino or dimethylamino; R.sup.3 represents hydrogen or loweralkyl; and n is 1 or 2 and their pharmaceutically acceptable acid addition salts have anxiolytic activity. In particular, they have activity against anxiety induced by the withdrawal from ingested substances such as narcotics (e.g. cocaine), alcohol and nicotine.
Claims16
A method for the treatment or prophylaxis of anxiety comprising the administration to a warm-blooded animal requiring such treatment or prophylaxis of an anxiolytically effective amount of a compound of general formula I:
- ##STR10## wherein:
- X represents oxygen or sulphur;
- R.sup.1 represents loweralkyl;
- R.sup.2 represents hydrogen, halo, 4,5-benzo, loweralkoxy, amino, methylamino or dimethylamino;
- R.sup.3 represents hydrogen or loweralkyl;
- and
- n is 1 or 2
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.