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US 4,908,365 AGranted
Benzhydryloxyethylpiperazine derivatives, processes for their preparation and pharmaceutical compositions in which they are present
OwnerAndre Buzas, Jean-Yves Merour +1inventors
InventorsAndre Buzas, Jean-Yves Merour, Roland Ollivier
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Abstract
The present invention relates to benzhydryloxyethylpiperazine derivatives of the formula: ##STR1## It also relates to processes for the preparation of the said derivatives and pharmaceutical compositions in which they are present. The said derivatives have an antihistaminic activity without a sedative component.
Claims16
Benzhydryloxyethylpiperazine derivatives corresponding to the formula II:
- ##STR29## in which:
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 independently of one another represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the trifluoromethyl group;
- n is an integer between 1 and 6 inclusive;
- and
- R.sub.5 and R.sub.6 represent in one case a hydrogen atom and in the other a benzoyl or benzoyl substituted with a member selected from the group consisting of hydroxyl, carboxyl and nitro, or R.sub.5 and R.sub.6 form, with the nitrogen atom to which they are bonded, a 5-membered or 6-membered heterocyclic group selected from the following groups:
- succinimidyl, 4-phenylsuccinimidyl, phthalimidyl, napthalimidyl, phthalimidinyl, 3-hydroxyphthalimidinyl, 2-oxobenzimidazolinyl, 3-benzyl-2-oxobenzimidazolinyl, 1,2,3,4-tetrahydro-2,4-dioxoquinazolinyl, 3,4-dihydro-4-oxoquinazolinyl, 3,4-dihydro-4-oxo-2-methylquinazolinyl, 3,7-dihydro-1,3-dimethyl-2,6-dioxo-1H-purinyl and 3,7-dihydro-3,7-dimethyl-2,6-dioxo-1H-purinyl.
3 more elements
Dependencies are inferred from the claim text.