Aldophosphamide derivatives useful as antitumor agents
AssigneeResearch Corporation Technologies, Inc.
InventorsRichard F. Borch, Ronald R. Valente
Life of this patent
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Abstract
A compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 may be the same of different and are each independently hydrogen or lower alkyl which may be unsubstituted or monosubstituted with halogen, lower alkoxy or hydroxy with the proviso that the substituent is not the .alpha.-carbon or R.sup.1 and R.sup.2 taken together with the carbon to which they are attached form a morpholino ring; each R.sup.3 is independently hydrogen, lower alkyl, carboxy or carbalkoxy; n is an integer from 0, 1, 2 or 3 and R is hydrogen, lower alkyl, cycloalkyl, arylalkyl aryl or a nitrogen, sulfur or oxygen containing heterocyclic or a heterocyclic lower alkyl and pharmacuetically acceptable salts thereof.
Claims19
A compound of the formula ##STR19## wherein R.sup.1 and R.sup.2 may be the same of different and are each independently hydrogen or lower alkyl which may be unsubstituted or monosubstituted with halogen or lower alkoxy or hydroxy with the proviso that the substituent is not on the .alpha.-carbon or R.sub.1 and R.sub.2 together with nitrogen to which they are attached from a morpholino ring;
- each R.sup.3 is independently hydrogen, lower alkyl, carboxy or carbalkoxy;
- n is an integer from 0, 1, 2 or 3 and
- R is hydrogen, lower alkyl, cycloalkyl, arylalkyl aryl or a nitrogen, sulfur or oxygen containing heterocyclic or a heterocyclic lower alkyl and pharmaceutically acceptable salts thereof.
A compound of the formula ##STR22## wherein R.sup.1 and R.sup.2 may be the same of different and are each independently hydrogen or lower alkyl which may be unsubstituted or monosubstituted with halogen, lower alkoxy or hydroxy with the proviso that the substituent is not on the .alpha.- carbon;
- or
- R.sup.1 and R.sup.2 taken together with the nitrogen to which they are attached from a morpholino ring,
- n is an integer from 0, 1, 2 or 3 and
- R is hydrogen, lower alkyl, cycloalkyl, arylalkyl aryl or a nitrogen, sulfur or oxygen containing heterocyclic or a heterocyclic lower alkyl and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.