Hyperosmotic/hyperoncotic solutions for resuscitation of hypodynamic shock
AssigneeThe Regents of the University of California
InventorsGeorge C. Kramer, James W. Holcroft
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Abstract
A physiologically acceptable solution which is both hyperosmotic and hyperoncotic with respect to blood plasma and has utility in treating patients experiencing or threatening to experience hypodynamic shock. The physiologically acceptable solution comprises a hyperosmotic concentration of a crystalloid (in excess of about 1800 mOsms) and hyperoncotic concentration of a colloid (in excess of about 30 mm Hg). The physiologically acceptable solution is easily administered by single, rapid infusion of approximately 4 to 5 ml/kg of body weight and results in a rapid and sustained normalization of circulatory function.
Claims20
A physiologically acceptable solution for treating hypodynamic circulatory shock in a mammal, said solution containing a crystalloid having a molecular weight less than about 1000 in a concentration of at least about 1800 mOsms and a colloid having a molecular weight in excess of 30,000 in a concentration so as to render said solution hyperoncotic relative to the colloidal osmotic pressure of the normal blood plasma of said mammal.
A physiologically acceptable solution comprising saline and dextran, having an osmolarity of about 2400 mOsms and an oncocity of about 70 mm Hg.
A method of preventing or treating hypodynamic circulatory shock in a mammal, comprising the step of administering to said mammal in a condition of existing or impending shock, a therapeutically effective dose of a physiologically acceptable solution, said solution containing a crystalloid having a molecular weight less than about 1000 in a concentration of at least about 1800 mOsms and a colloid having a molecular weight in excess of 30,000 in a concentration so as to render said solution hyperoncotic relative to the colloidal osmotic pressure of the normal blood plasma of said mammal.
Dependencies are inferred from the claim text.