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AssigneeAmics AG
InventorsRolf Schafer, Hans Hitz
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From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and which extract can be also used for controlling acne vulgaris. The corresponding extracts are used as active ingredients of corresponding pharmaceutical preparations. The new pharmaceutically active extract is prepared according to a process in which polar substances having a molecular weight below 5000 are isolated from the embryonic mammalian organs avoiding any degradation of substances having a higher molecular weight. The finely divided embryonic mammalian organs are extracted with a mixture of water and a water soluble organic solvent which contains nor more than 30 vol.-% of water at an about neutral pH value for stirring and refluxing. The resulting solution is then submitted to a predetermined sequence of further drying steps, heating steps and cooling steps, and finally to a filtration with an ultramembrane filter in order to remove any substances having a molecular weight of about 5000. The extract is then finally concentrated under vacuum to yield a liquid concentrate or a dry residue.
In a process for preparing an extract of finely divided embryonic mammalian organs, which is free of non-polar constituents and constituents having a high molecular weight, by treatment with a mixture of water and a water soluble organic solvent, the improvement comprising
In a process for preparing an extract of finely divided embryonic mammalian organs, which is free of non-polar constituents and constituents having a high molecular weight, by treatment with a mixture of water and a water soluble organic solvent, the improvement comprising
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