Stabilized human tissue plasminogen activator compositions
AssigneeGenentech, Inc.
InventorsWilliam F. Bennett, Stuart E. Builder, Larry A. Gatlin
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Abstract
Disclosed are novel, stable pharmaceutically acceptable compositions containing human tissue plasminogen activator, featuring, for example, an argininium ion containing buffer as a component. Also disclosed are associated means and methods for preparing and using such compositions in various forms.
Claims17
A pharmaceutical composition comprising a pharmaceutically effective amount of human tissue plasminogen activator and a pharmaceutically acceptable argininium ion containing buffer, said composition having a chloride ion concentration of less than about 0.3M, and a pH of approximately 5.
A pharmaceutical composition comprising a pharmaceutically effective amount of human tissue plasminogen activator and a pharmaceutically acceptable argininium ion containing buffer, said composition having a chloride ion concentration of less than about 0.3M, and a pH of approximately 6.
Dependencies are inferred from the claim text.