Process for the preparation of 7-(2-diethylaminoethyl)-theophylline acetyl salicylate and use thereof
AssigneeLaboratories Boi, S.A.
InventorConcepcion Coma Julia
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Abstract
A process for the preparation of 7-(2-diethylaminoethyl)-theophylline acetylsalicylate and use of the product obtained. The process comprises prior filtering of a solution of the reactants through a layer of diatomaceous earth and activated carbon, cooling and treatment with a source of high frequency ultrasounds. The product is used in the manufacture of anti-agglutination and anti-thrombotic agents. The process provides products having a high level of purity.
Claims3
A process for the preparation of 7-(2-diethylaminoethyl)-theophylline acetylsalicylate, characterised in that it comprises the steps of forming a solution of acetylsalicylic acid and 7-(2-diethylaminoethyl)-theophylline in an inert solvent, filtering said solution through a layer of diatomaceous earth and activated carbon, to give a filtered solution, cooling said solution to a temperature lying between 1.degree. and 8.degree. C. and treating said solution with an ultrasound source at a frequency lying between 40 and 60 KHz.
The process of any one of the foregoing claims, characterised in that said inert solvent is tert.butylmethyl ether.
Dependencies are inferred from the claim text.