Process for the preparation of vitamin A
AssigneeRhone-Poulenc Sante
InventorsJean-Michel Grosselin, Claude Mercier
Life of this patent
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Abstract
Vitamin A containing practically no 2-cis or 6-cis isomer is prepared by hydrogenation of the aldehyde of vitamin A, optionally in the form of a complex with hydroquinone, in the presence of a ruthenium hydride catalyst.
Claims11
A process for the preparation of vitamin A containing practically no 2-cis or 6-cis isomer which comprises reducing retinal with hydrogen in a polar organic solvent selected from the group consisting of alcohols of 1 to 3 carbon atoms, and mixtures of an alcohol of 1 to 3 carbon atoms with an aliphatic, alicyclic or aromatic hydrocarbon, an ether or an ester, in the presence of a catalyst selected from the group consisting of ruthenium hydrides and ruthenium hydrides associated with a ligand containing phosphorus, oxygen, nitrogen, sulphur or silicon.
Dependencies are inferred from the claim text.