Back to results
US 4,906,757 AGranted
Process for the preparation of dextrorotatory 3-(3-pyridyl)-1H,3H-pyrrolo [1,2-c]-7-thiazolecarboxylic acid
AssigneeRhone-Poulenc Sante
InventorGerard H. Rajoharison
Life of this patent
Estimating the term…
Abstract
The acid of formula: ##STR1## is prepared by reaction of an ester of 2-chloroacrylic acid with an organic salt of 2R, 4R (or predominantly 2R, 4R) 3-formyl-2-(3-pyridyl)-4-thiazolidinecarboxylic acid in the presence of an acid chloride and of triethylamine and then saponifying the ester obtained.
Claims7
A process for the preparation of dextrorotatory 3-(3-pyridel)-1H,3H-pyrrolo[1,2-c]-7-thiazolecarboxylic acid of the formula:
- ##STR8## which comprises reacting an ester of 2-chloroacrylic acid of formula:
- ##STR9## in which R denotes alkyl of 1 to 4 carbon atoms in a straight or branched chain, benzyl, or aryl, with an organic salt of 2R,4R 3-formyl-2-(3-pyridyl)-4-thiazolidinecarboxylic acid of the formula:
- ##STR10## in the presence of an acid chloride and of triethylamine to produce an ester of the formula:
- ##STR11## in which R is as hereinbefore defined, and saponifying the ester of formula (VII) under nonracemizing conditions.
1 more element
Dependencies are inferred from the claim text.