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US 4,906,756 AGranted
2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
AssigneeSyntex (U.S.A.) Inc.
InventorsEric Lodewijk, Hiralal N. Khatri
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Abstract
An improved process for the reduction of 2-(2-nitrovinyl)thiophene to form 2-(2-thienyl)ethylamine employs a boron-containing reducing agent, preferably diborane. The 2-(2-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.
Claims10
A process for making 2-(2-thienyl)ethylamine, wherein said process comprises reacting 2-(2-nitrovinyl)thiophene with a boron-containing reducing agent.
A process for making ticlopidine, said process comprising the steps of:
- a. reacting 2-(2-nitrovinyl)thiophene with diborane to give 2-(2-thienyl)ethylamine, and
- b. converting said 2-(2-thienyl)ethylamine to ticlopidine.
Dependencies are inferred from the claim text.