Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds

A compound of the formula:

• ##STR5## wherein the two lines to both A and B indicate a double bond to a single group or two single bonds to two individual groups as specified;
• A is (H)(H), .dbd.O, (H)(OH) or .dbd.N--OH;
• B is (H)(H), (H)(CH.sub.3), (H)(CH.sub.2 NR.sub.3 R.sub.4) or .dbd.CH.sub.2 wherein R.sub.3 and R.sub.4 are C.sub.2-4 alkyl or are combined to give tetramethylene, pentamethylene or --CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 --;
• R.sub.1 is ##STR6## wherein Z is NR.sub.9, O or S;
• R.sub.5 ;
• R.sub.6 and R.sub.8 are each hydrogen, halogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxy;
• R.sub.7 is hydrogen, amino, (C.sub.1-4 alkyl)amino, (C.sub.1-4 alkyl).sub.2 amino, C.sub.1-3 alkoxy or nitro;
• R.sub.9 is hydrogen, C.sub.1-4 alkyl or phenyl(C.sub.1-2 alkyl);
• R.sub.10 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, cyano or --CONH.sub.2 ;
• R.sub.11 is hydrogen, halogen, C.sub.1-4 alkyl or phenyl;
• the wavy line indicates that the configuration of the oxygen substitutent on the ring can be endo or exo;
• and the pharmaceutically acceptable acid addition and quaternary ammonium salts of the aforesaid compounds.