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US 4,906,749 AGranted
Cyclic anhydride derivatives of chromophors
AssigneeViomedics Inc.
InventorSpyros Theodoropulos
Life of this patent
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Abstract
Novel chromophor derivatives of cyclic anhydrides are provided which have the ability to react with a variety of organic substrates forming adducts which are useful in analytical techniques for the detection and measurement of biological compounds.
Claims21
An adduct of an anhydride derivative of chromophors having the structural formula:
- ##STR7## wherein R is an organic chromophoric group exhibiting fluorescence, luminescence, chemiluminescence or absorption properties;
- Z is hydrogen, alkyl, aryl, or a heterocyclic group composed of carbon ,hydrogen and at least one of oxygen, nitrogen or sulfur, and wherein Z contains from 1 to 20 carbon atoms;
- each X contains 2 to 3 straight chain carbon atoms connecting the carbonyl groups;
- and Y is a divalent or polyvalent group comprised of carbon, hydrogen, and optionally oxygen, and contains up to 20 carbon atoms, and provides at least one single or multivalent alkyl, alkenyl, cycloalkyl, bicycloalkyl, bicyloalkenyl, aryl or carbonyl containing group bridging the carbonyl-containing moieties through one or ore of the carbon atoms of the X groups;
- L is nitrogen or oxygen;
- S is an organic substrate;
- and R' is hydrogen or alkyl, aryl or heterocyclic, of from 1 to 20 carbon atoms;
- and n is 0 or 1, with the proviso that when L is oxygen n is 0.
5 more elements
The adduct of claim I wherein the anhydride derivative of the chromophor has the structural formula:
- ##STR14## wherein R and Z are as indicated.
Dependencies are inferred from the claim text.