Cephem derivative crystals
AssigneeEisai Co., Ltd.
InventorsKazuhide Ashizawa, Kiyohiko Uchikawa, Tadashi Sato, Yasuo Ishibashi
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Abstract
Disclosed herein are 7.beta.-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3- (4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate crystals comprising X-ray diffraction pattern possessing the characteristic diffraction intensity at the spacing d (unit: angstrom) shown in the following (i), (ii) or (iii): (i): 6.2, 5.1 and 5.0; (ii): 10.6, 5.3 and 5.1; (iii): 15.4, 5.0 and 4.6. A process for the preparation of the crystals is also disclosed.
Claims9
7.beta.-[(Z)-2-( 5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-(4-carbamoyl-1-qu inuclidinio)-methyl-3-cephem-4-carboxylate crystals comprising X-ray diffraction pattern possessing the characteristic diffraction intensity at the spacing d (unit:
- angstrom) shown in the following (i), (ii) or (iii):
- (i):
- 6.2, 5.1 and 5.0;
- (ii):
- 10.6, 5.3 and 5.1;
- (iii):
- 15.4, 5.0 and 4.6.
A process for the preparation of crystals comprising X-ray diffraction pattern possessing the characteristic diffraction intensity at the spacing d (unit:
- angstrom) shown in the following (i), (ii) or (iii), which comprises crystallizing out 7.beta.-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3- (4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate from a mixed solvent of water and methanol and then drying the same so that the water content may be decreased to 30% (W/W) or less:
- (i):
- 6.2, 5.1 and 5.0;
- (ii):
- 10.6, 5.3 and 5.1;
- (iii):
- 15.4, 5.0 and 4.6.
Dependencies are inferred from the claim text.