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AssigneesNisshin Flour Milling Co., Ltd., Grelan Pharmaceutical Co., Ltd.
InventorsKazuhiko Yamada, Yoshiyuki Tahara, Masashi Toyoda, Osamu Irino, Noriyuki Misaki
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Anti-ulcer agents containing isoprenoid derivatives are provided. The isoprenoid derivatives are represented by the formula: ##STR1## wherein: R represents a group of formula ##STR2## In the above formula, R.sub.1, R.sub.2 and R.sub.3 may be the same or different each other and each represents a hydrogen atom, a hydroxy group, a lower alkanoyloxy group, a lower alkyl group or a lower alkoxy group, provided that two or more of them do not represent hydrogen atoms at the same time; R.sub.4 and R.sub.5 may be the same or different each other and each represents a hydrogen atom, a hydroxy group or a lower alkanoyloxy group represents the signal or the double bond between the carbon atoms; m represents 0 or 1; n represents 0 or an integer of from 1 to 9, provided that the sum of m and n is an integer of from 1 to 9.
A composition which comprises an anti-ulcer isoprenoid derivative represented by the formula (I) ##STR7## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different from each other and each represents a hydrogen atom or a hydroxy group and at least two of R.sub.1, R.sub.2 and R.sub.3 represent hydroxy groups, represents a single or a double bond between the carbon atoms, m represents 0 or 1 and n represents 0 or an integer of from 1 to 9 and the sum of m and n is an integer of from 1 to 9 except that when represents a double bond and two of R.sub.1, R.sub.2 and R.sub.3 are hydroxy groups and the other is a hydrogen atom, the sum of m and n is 2-8, and pharmaceutically acceptable additives.
A method comprising treating an ulcer in mammals by administering a therapeutically effective amount to treat an ulcer of an isoprenoid derivative represented by the formula (I) ##STR8## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different from each other and each represents a hydrogen atom or a hydroxy group and at least two of R.sub.1, R.sub.2 and R.sub.3 represent hydroxy groups, represents a single or a double bond between the carbon atoms, m represents 0 or 1 and n represents 0 or an integer of from 1 to 9, and the sum of m and n is an integer of from 1 to 9, to said mammals.
An isoprenoid derivative represented by the formula (Ia) ##STR9## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different from each other and each represents a hydrogen atom or a hydroxy group provided that two or more of them do not represent hydrogen atoms at the same time, represents a single or a double bond between the carbon atoms, m' represents 1 and n' represents 3, 4 or 8 provided that represents a double bond when n' is 8 and represents a single bond when n' is 3 or 4.
Dependencies are inferred from the claim text.