US 4,906,659 A · Antibiotic tan-749, its derivatives, production and use thereof

Abstract

A compound of the formula ##STR1## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tettrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.

Claims50

Dependent claims

A compound of the formula ##STR497## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted;

with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tetrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, or a pharmaceutically acceptable salt thereof.

A compound of the formula ##STR498## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted;

with the proviso that when R.sup.1 is amino, sorbylamino or hexanoylamino, R.sup.2 is hydrogen or methyl, R.sup.4 is amino which may be protected and R.sup.5 is hydroxyl or 2-amidinoethylamino, R.sup.3 is a protecting group, and that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tetrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Antibiotic tan-749, its derivatives, production and use thereof

Life of this patent

Antibiotic tan-749, its derivatives, production and use thereof

Life of this patent

Abstract

Claims50