Back to results
US 4,906,655 AGranted
Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
AssigneeWarner-Lambert Company
InventorsDavid C. Horwell, David C. Rees
Life of this patent
Estimating the term…
Abstract
Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents having very high kappa-opioid affinity and selectivity and potency and useful as analgesics, diuretics, antiinflammatory and psychotherapeutic agents are disclosed. Methods for making the compounds and pharmaceutical compositions containing them are also disclosed.
Claims16
A compound of formula ##STR13## and the pharmaceutically acceptable acid addition salts thereof wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 =H;
- or
- wherein one of R.sub.1, R.sub.2, R.sub.3, R.sub.4 may be =OCH.sub.3 when the rest are all H;
- or
- wherein R.sub.1 =R.sub.4 =OCH.sub.3, and R.sub.2 =R.sub.3 =H;
- Ar is ##STR14## wherein X is hydrogen, fluorine, chlorine, alkyl of from one to six carbon atoms or aryl,
- n is an integer from 2 to 4, and
- A is oxygen or sulfur.
4 more elements
Dependencies are inferred from the claim text.