Stabilized pharmaceutical compositions
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsShozo Kouchiwa, Masami Nemoto, Tetsuo Yamaguchi, Atsuro Nakazato
Life of this patent
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Abstract
Stabilized solid pharmaceutical preparations in which one or more of sodium carbonate, sodium hydrogen carbonate, calcium carbonate and calcium hydrogen phosphate are incorporated in a solid composition containing a 1,4-dihydropyridine derivative as an active ingredient. The present compositions are used as an oral therapeutic agent for the circulatory system, especially as a coronary vasodilator.
Claims5
A solid pharmaceutical composition containing, as an active ingredient in an amount therapeutically effective in the treatment of circulatory disease, a 1,4-dihydropyridine derivative represented by the general formula ##STR5## wherein R is a n-propyl group substituted at the 2- or 3-position with a nitrato group and R.sup.1 is a 2-nitratoethyl group or 2-nitratoethyl substituted with a methyl group at the 1- or 2-position and, in an amount sufficient to stabilize said derivative, one or more compounds selected from the group consisting of sodium carbonate, sodium hydrogen carbonate, calcium carbonate and calcium hydrogen phosphate.
A method for stabilizing a solid pharmaceutical composition containing, as an active ingredient in an amount threapeutically effective in the treatment of circulatory disease, a 1,4-dihydropyridine derivative represented by the general formula ##STR6## (wherein R is a n-propyl group substituted at the 2or 3-position with a nitrato group and R.sup.1 is a 2-nitratoethyl group which may be substituted with a methyl group at the 1- or 2-position) and pharmaceutical auxiliary agents which comprises incorporating in the composition, in an amount sufficient to stabilize said derivative, one or more compounds selected from the group consisting of sodium carbonate, sodium hydrogen carbonate, calcium carbonate and calcium hydrogen phosphate.
Dependencies are inferred from the claim text.