Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class
AssigneeBoard of Governors of Wayne State University
InventorsKenneth V. Honn, John D. Taylor, James M. Onoda
Life of this patent
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Abstract
A method for the treatment of malignant tumors by co-administering a platinum coordination compound and a dihydropyridine class calcium channel blocker compound is described. The compounds are administered over a period of several days in at least two separate dosages of each compound so as to produce regression of the tumor in vitro and in vivo and inhibition of metastasis of the tumor in vivo.
Claims19
A method for the treatment of a malignant tumor in vitro or in vivo in a mammal which comprises administering to the tumor a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of ##STR4## wherein R.sub.1 and R.sub.2 are methyl groups, R.sub.3 and R.sub.4 are alkyl or alkyloxyalkylene groups containing 1 to 8 carbon atoms and R.sub.5 and R.sub.6 are hydrogen or one or two electron withdrawing substituents along with a platinum coordination compound in effective amounts so as to increase regression of the tumor over regression achieved with the plastimum coordination compound alone or to reduce metastasis of the tumor or to achieve regression of the tumor and reduction of metastasis.
Ammethod for the treatment of a malignant tumor in vivo in a mammal which comprises administering to the tumor a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of ##STR5## wherein R.sub.1 and R.sub.2 are methyl groups and R.sub.3 and R.sub.4 are alkyl or alkyloxyalkylene groups containing 1 to 8 carbon atoms and R.sub.5 and R.sub.6 are hydrogen or one or two electron withdrawing groups along with a platinum coordination compound in affective amounts and in at least two separate dosages of each compound over a period of days to increase regression of the tumor over the regression achieved with the platinum coordination compound alone or to reduce metastasis of the tumor or to both achieve regression and reduction of metastasis.
A composition for the treatment of malignant tumors in vivo in a mammal which comprises:
- (a) a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of ##STR6## wherein R.sub.1 and R.sub.2 are methyl groups, R.sub.3 and R.sub.4 are alkyl or alkyloxyalkylene groups containing 1 to 8 carbon atoms and R.sub.5 and R.sub.6 are hydrogen or one or two electron withdrawing substituents;
- and
- (b) a platinum coordination compound which has antitumor properties in humans wherein the weight ratio of the calcium channel blocker compound to the platinum coordination compound is between 1 and 10 and 10 to 1.
Dependencies are inferred from the claim text.