Lipid-peroxide formation inhibiting composition and novel compounds useful therefor
AssigneeMitsubishi Kasei Corporation
InventorsYasuhiro Morinaka, Hiroyoshi Nishi, Toshiaki Watanabe, Satoshi Yuki, Hiroko Sakurai, Yoshio Hayashi, Nobuko Fukushima
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Abstract
A lipid-peroxide formation inhibitor useful as a preventive medicine and/or therapeutic medicine against various ischemic diseases and accompanying diseases such as various brain diseases, heart diseases and peripheral circulatory diseases and novel pyrazolone derivatives having such inhibitory activity and their pharmaceutically acceptable salts.
Claims6
A method of inhibiting lipid-peroxide formation in a subject requiring such treatment which comprises administering a composition which comprises as the effective ingredient a lipid peroxide inhibiting amount of at least one of the pyrazolone derivatives which are expressed by the following general formula (I') or (I"):
- ##STR81## wherein R.sup.1 is an aryl group which can contain substituent(s) R.sup.2 is a hydrogen atom or an alkyl group, R.sup.3 is a pyridyl group and n is zero or one, and pharmaceutically acceptable salts thereof.
Pyrazolone derivatives of the following general formula (Ia') or (Ia"):
- ##STR82## wherein R.sup.1 represents a phenyl group which may contain substituent(s) selected from the group consisting of straight-chain or branched saturated alkyl groups of from 1 to 5 carbon atoms, straight-chain or branched saturated alkoxy groups of from 1 to 5 carbon atoms, halogen atoms, saturated alkoxycarbonyl groups of from 2 to 5 total carbon atoms, carboxyl group, alkoxycarbonylalkyl groups of from 3 to 6 total carbon atoms, carboxymethyl group, straight-chain saturated alkylmercapto group of from 1 to 3 carbon atoms, trifluoromethyl group and hydroxyl group, R.sup.2 is a hydrogen atom or an alkyl group, R.sup.3 is a pyridyl group and n is zero or one, provided that, when n is zero R.sup.1 represents a phenyl group which may contain substituent(s) selected from the group consisting of straight-chain or branched saturated alkoxy groups of from 1 to 5 carbon atoms, halogen atoms, alkoxycarbonylalkyl groups of from 3 to 6 total carbon atoms, carboxymethyl group, straight-chain saturated alkylmercapto groups of from 1 to 3 carbon atoms, trifluoromethyl group and hydroxyl group, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.