Amide derivatives and antiallergic agents containing the same
AssigneeTerumo Kabushiki Kaisha
InventorsShin Hattori, Makoto Takai, Kazuhiro Omori, Shinji Ozawa, Toshio Wakabayashi
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Abstract
Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]-aminoethyl ]-4-benzhydroxypiperidine, 1-[2-[3-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2-propenoyl]-4-benzhydroxypi peridine, 1-[3-[-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]aminopropyl] -4-benzhydrylpiperazine and the like. These amide derivatives are useful as antiallergic agents.
Claims10
An amide derivative represented by the formula (I) ##STR10## wherein R.sup.1 represents a lower alkoxy group or a lower alkoxycarbonyloxy group, R.sup.2 represents a lower alkoxycarbonyloxy group, R.sup.3 represents a hydrogen atom, m represents an integer of 1 or 2 and Y represents a group represented by the formula (III) ##STR11## wherein X represents a hydrogen atom, a halogen atom or a methyoxy group and q represents an integer of from 2 to 4.
The method according to claim 6 wherein R.sup.1 and R.sup.2 respectively represent an ethoxycarbonyloxy group and R.sup.3 represents a hydrogen atom.
A pharmaceutical composition of matter for treatment of allergic conditions, said method comprising administering to animals in need of such treatment an effective amount to treat allergic conditions of an amide derivative represented by the formula (I) ##STR12## wherein R.sup.1 represents a lower alkoxy group or a lower alkoxycarbonyloxy group, R.sup.2 represents a lower alkoxycarbonyloxy group, R.sup.3 represents a hydrogen atom, m represents an integer of 1 or 2 and Y represents a group represented by the formula (III) ##STR13## wherein X represents a hydrogen atom, a halogen atom or a methoxy group and q represents an integer of from 2 to 4 and a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.