Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
AssigneeRorer Pharmaceutical Corporation
InventorsWilliam L. Studt, William C. Faith, Bruce F. Molino
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Abstract
A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.
Claims18
A method for increasing cardiotonic contractility in a human or other mammal requiring such treatment which comprises administering thereto an effective inotropic amount of compound according to the formula ##STR22## wherein:
- x is 0 to 1;
- Y is ##STR23## a and b are 0, 1 or 2, provided that a+b is not greater than 2;
- R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are each independently H, alkyl or aralkyl;
- R and R.sup.5 are H or alkyl;
- R or R.sup.5 groups on vicinal carbon atoms may together form a carbon-carbon double bond;
- and
- geminal R.sup.4 and R.sup.5 groups may together form a spiro substituent, --(CH.sub.2).sub.d --, where d is 2 to 5;
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition for increasing cardiotonic contractility in a patient requiring such treatment comprising a pharmaceutically acceptable carrier in admixture with a compound described by the formula ##STR24## wherein:
- x is 0 or 1;
- Y is ##STR25## a and b are 0, 1 or 2, provided that a+b is not greater than 2;
- R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are each independently H, alkyl or aralkyl;
- R and R.sup.5 are H or alkyl;
- R and R.sup.5 groups on vicinal carbon atoms may together form a carbon-carbon double bond;
- and
- geminal R.sup.4 and R.sup.5 groups may together form a spiro substituent, --(CH.sub.2).sub.d --, where d is 2 to 5;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.