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US 4,906,628 AGranted
N-phenylpyridone type III phosphodiesterases
AssigneeSmith Kline & French Laboratories Limited
InventorWilliam J. Coates
Life of this patent
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Abstract
Phosphodiesterase (type III) inhibitors having the formula: ##STR1## which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
Claims13
A compound of the formula (1):
- ##STR39## or a pharmaceutically acceptable salt thereof, wherein:
- R.sup.1 is hydrogen, or R.sup.1 and R.sup.2 together form a bond;
- R.sup.2 is hydrogen or methyl, or R.sup.1 and R.sup.2 together form a bond;
- and
- R.sup.3 is hydrogen.
2 more elements
A compound according to claim 26 wherein R.sup.1 is hydrogen and R.sup.2 is hydrogen or methyl, or R.sup.1 and R.sup.2 together form a bond.
Dependencies are inferred from the claim text.