3-Imidazolium cephalosporin derivatives
AssigneeOtsuka Kagaku Kabushiki Kaisha
InventorsKiyotoshi Matsumura, Hiroshi Akagi, Daisuke Suzuki, Akihiro Shimabayashi
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Abstract
A cephalosporin compound substituted by imidazolium ring in 3-position of cephem having the following formula (I), and pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 is an organic residue known in .beta.-lactam antibiotics, R.sup.2 is hydrogen atom or methoxy, n is 0 or 1, A is a nitrogen-containing group constituting imidazolium ring, is useful as an agent for preventing and treating bacterial infections.
Claims6
A cephalosporin compound substituted by an imidazolium ring in 3-position of cephem having the formula (I) or (II) ##STR119## wherein R.sup.1 is ##STR120## wherein R.sup.9 is C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl;
- R.sup.2 is hydrogen or methoxy;
- R.sup.4 is C.sub.2 -C.sub.12 alkenyl or C.sub.2 -C.sub.12 alkynyl;
- and n is 0 to 1.
Dependencies are inferred from the claim text.