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AssigneeEgis Gyogyszergyar
InventorsLaszlo Rozsa, Lujza Petocz, Eniko Szirt nee Kiszelly, Peter Tompe, Gabor Gigler
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The invention relates to optically active 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxaz ocine of the Formula ##STR1## and pharmaceutically acceptable acid additional salts thereof. The enantiomers are especially active against Parkinsion's disease. The optically active enantiomers are prepared by (a) resolving the racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-dioxa zocine with a optically active organic acid and separating the enantiomers; or (b) dissolving the racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-dioxa zocine in an organic solvent, crystallizing and isolating one of the enantiomers, optionally dissolving additional racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-dioxa zocine in the mother liquor obtained and crystallizing and isolating the other enantiomer, and, if desired, repeating the whole process.
2-Chlo ro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine in optically active form or a pharmaceutically acceptable acid addition salt thereof.
(+)-2-Chlor o-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine or a pharmaceutically acceptable acid addition salt thereof.
(-)-2-Chloro-12-(3-dimethylamino-2-methylpropyl)-12H-di benzo[d,g][1,3,6]dioxazocine or a pharmaceutically acceptable acid addition salt thereof.
A pharmaceutical composition for treating Parkinson's disease comprising 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxaz ocine in optically active form or a pharmaceutically acceptable acid addition salt thereof and one or more pharmaceutical carrier(s).
A method of treating Parkinson's disease which comprises administering to a mammolian subject a therapeutically effective amount of an optically active 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxaz ocine or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.