Polymers based on polyvinylene carbonate and/or polyhydroxymethylene as carriers for biologically active substances
AssigneeHoechst Aktiengesellschaft
InventorOtto Mauz
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Abstract
Modified polymers based on polyvinylene carbonate and/or polyhydroxymethylene are prepared containing covalently bonded units derived from particular alkoxylated compounds. Polymerization is carried out in the presence of the alkoxylated compounds and a particular dispersion stabilizer. The modified polymer is suitable as a carrier for biologically active substances or for affinity chromatography.
Claims14
A carrier-bonded biologically active substance comprising a biologically active substance bound directly or through a spacer to a polymer which consists substantially of a base polymer which comprises units (II) or a mixture of units (I) and (II) containing more than 50% by weight of units (II) based on said mixture, said units (I) and (II) having the following structural formulas ##STR4## in which R.sub.1 and R.sub.2 are hydrogen or a monovalent hydrocarbon radical with up to 8 carbon atoms, which polymer also contains convalently bonded units which are derived from at least one compound of formula (III) ##STR5## in an amount of greater than 0% and up to 30% by weight, based on the base polymer, and which are grafted onto the base polymer in which:
- R.sub.3 is a hydrocarbon radical with 4 to 30 carbon atoms;
- X is a member selected from the group consisting of --O--, COO-- and mixture thereof;
- R.sub.4 and R.sub.5 are hydrogen or a monovalent hydrocarbon radical with 1 to 8 carbon atoms, with the proviso that at least one of the radicals R.sub.4 and R.sub.5 is hydrogen;
- m is an integer from 1 to 40;
- and
- n is an integer from 1 to 4.
A process for the preparation of a carrier-bonded biologically active substance which comprises a polymer consisting substantially of a base polymer having units (II) or a mixture of units (I) and (II) containing more than 50% by weight of units (II) based on said mixture, said units (I) and (II) having the following structural formulas ##STR6## in which R.sub.1 and R.sub.2 are hydrogen or a monovalent hydrocarbon radical with up to 8 carbon atoms, which polymer also contains units which are derived from at least one compound of formula (III) ##STR7## in an amount of greater than 0% and up to 30% by weight, based on the base polymer, which are grafted onto the base polymer in which:
- R.sub.3 is a hydrocarbon radical with 4 to 30 carbon atoms;
- X is a member selected from the group consisting of --O--, COO-- and mixture thereof;
- R.sub.4 and R.sub.5 are hydrogen or a monovalent hydrocarbon radical with 1 to 8 carbon atoms, with the proviso that at least one of the radicals R.sub.4 and R.sub.5 is hydrogen;
- m is an integer from 1 to 40;
- and
- n is an integer from 1 to 4,
- which process comprises polymerizing a compound of the formula (IV) ##STR8## in which R.sub.1 and R.sub.2 are as defined above, in a liquid dispersant in the presence of a free radical initiator, a dispersion stabilizer, and at least one compound of the formula (III), in which R.sub.3, R.sub.4, R.sub.5, X, m and n are as defined above, said dispersion stabilizer being a copolymer of maleic anhydride and at least one comonomer component selected from the group consisting of a vinyl alkyl ether, a vinyl ester and a long-chain alphaolefin to obtain a graft polymerization polymer product containing units (I), and hydrolyzing the majority of the units (I) to obtain units (II) followed by contacting the resultant hydrolyzed polymer product
- with a biologically active substance to obtain said carrier-bonded biologically active substance.
Dependencies are inferred from the claim text.