Novel liposome composition for sustained release of steroidal drugs in lungs
AssigneeLiposome Technology, Inc.
InventorRamachandran Radhakrishnan
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Abstract
This invention relates to a novel, non-conventional liposome formulation for the sustained release and delivery of steroids. The formulation provides prolonged release of the drug, improved therapeutic ratio, lower toxicity, reduced systemic side effects and is stable for several months.
Claims24
A liposome composition delivered by inhalation consisting essentially of a nonphosphlipid lipid mixture of cholesterol and cholesterol salt, said salt being selected from the group consisting of sulphatae, phosphate, nitrate and maleate, the ratio of cholesterol salt to cholesterol to a drug being from 30 to 70 mole % of cholesterol salt, from 20 to 50 mole % of of a cholesterol and 0.01 to 20 mole % of the steroidal drug.
A method of treating pulmonary disease by administering to the person in need of such treatment a therapeutically effective amount of a liposome composition consisting essentially of a drug and a nonphospholipid lipid mixture of cholesterol and cholesterol salt, said salt being selected from the group consisting of sulphate, a phosphate, nitrate and meleate.
An inhalation method for treatment of lung diseases by administering through the inhalation route to the person in need of such treatment a therapeutically effective amount of liposome composition consisting essentially of a steroidal drug and a nonphospholipid lipid mixture of cholesterol and cholesterol salt, said salt being selected from the group consisting of sulphate, phosphate, nitrate and meleate.
A process of preparing a liposome steroidal composition comprising:
- (a) mixing a cholesterol salt, cholesterol and a steroid drug in an appropriate ratio;
- (b) dissolving the mixture in a solvent;
- (c) lyophilizing the mixture;
- (d) resuspending the residue in a buffer;
- (e) preparing the liposomes;
- and
- (f) optionally extruding the steroidal liposomes through the filter.
Dependencies are inferred from the claim text.