Estradiol transdermal delivery system
AssigneePaco Pharmaceutical Services, Inc.
InventorBenjamin K. Kim
Life of this patent
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Abstract
The present invention is directed to a transdermal delivery system for an active substance. The active substance is estrogen or its derivatives and preferably is 17-beta-estradiol. The system comprises an impermeable backing layer and a matrix affixed thereto. The matrix comprises, on a weight percentage basis, from about 60 to about 95% of an adhesive polymer, from about 5 to about 20% of a solvent, from about 0.2 to about 4% of a skin penetration enhancer, and from about 0.5 to about 5% of the active substance. The system is free of any discrete permeable, polymeric, diffusion-controlling membrane.
Claims8
A transdermal delivery system comprises:
- an impermeable backing layer;
- a matrix affixed to said backing layer and comprising on a weight percentage basis from about 60 to about 95% of an adhesive vinyl acetate-acrylate multipolymer, from about 5 to about 20% of a solvent, from about 0.2 to about 4% of a skin penetration enhancer, and from about 0.5 to about 5% of an active substance selected from the group consisting of estrogen, derivatives of estrogen and combinations thereof;
- and
- said system being free of any discrete, permeable, polymeric, diffusion-controlling membrane.
A transdermal delivery system comprises:
- an impermeable backing layer;
- a matrix affixed to said backing layer and comprising on a weight percentage basis from about 60 to about 95% of an adhesive vinyl acetate-acrylate multipolymer, from about 5 to about 20% of a solvent selected from the group consisting of propylene glycol, propylene glycol derivatives and combinations thereof, from about 0.2 to about 4% of a polyoxyethylene ester skin penetration enhancer, and from about 0.5 to about 5% of an active substance selected from the group consisting of estrogen, derivatives of estrogen and combinations thereof;
- and
- said system being free of any discrete, permeable, polymeric, diffusion-controlling membrane.
Dependencies are inferred from the claim text.