Appropriate cytotoxic pharmaceutical combination especially for the treatment of cancers

A method for selectively destroying target cells carrying at least one antigen which comprises contacting the antigen carrying target cells with at least one preformed cytotoxic conjugate-antibody complex formed from at least one first antibody or antibodies which is selective for at least one antigen on the target cells and which binds thereto, the said first antibody being characteristic of an animal species different from that of the target cells, and at least one cytotoxic conjugate comprising the A chain of ricin covalently bound to an antibody specific for the immunoglobulins of the animal species to which said first antibody or antibodies belong in order to fix the cytotoxic conjugate-antibody complex to the target cell so that the target cell is destroyed.

A cytotoxic pharmaceutical composition for selectively destroying target cells carrying at least one antigen and comprising a cytotoxic effective amount of a complex formed from at least one first antibody or antibodies which is selective for at least one antigen on target cells and which binds thereto, the said first antibody being characteristic of an animal species different from that of the target cells, and at least one cytotoxic conjugate comprising the A chain of ricia covalently bound to an antibody specific for the immunoglobulins of the animal species to which the said first antibody or antibodies belong;

• and a pharmaceutically acceptable carrier.

A kit for selectively destroying target cells carrying at least one antigen which comprises, separately packaged, a pharmaceutical composition containing at least one first antibody or antibodies which is selective for at least one antigen on the target cells to be destroyed and which binds thereto, said first antibody being characteristic of an animal species different from that of the target cells;

• and separately packaged, a cytotoxic composition containing a cytotoxic effective amount for the target cells of at least one cytotoxic conjugate comprising the A chain of ricin covalently bound to an antibody specific for the immunoglobulins of the animal species to which the said first antibody or antibodies belong.

A cytotoxic pharmaceutical composition for selectively destroying target cells carrying at least one antigen which comprises at least one first antibody or antibodies which is selective for at least one antigen on the target cells and which binds thereto, said first antibody being characteristic of an animal species different from that of the target cells, and a cytotoxic effective amount of at least one cytotoxic conjugate comprising the A chain of ricin covalently bound to an antibody specific of the immunoglobulins of the animal species to which the said first antibody or antibodies belong and a pharmaceutically acceptable carrier.