Antithrombogenic devices containing polysiloxanes
AssigneeMassachusetts Institute of Technology
InventorsElliot L. Chaikof, Cynthia Sung, Edward W. Merrill
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Abstract
A crosslinked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane is described. These materials demonstrate low in vivo platelet retention as well as a low thrombogenicity. As such, they can provide antithrombogenic properties to blood contacting devices such as catheters, artificial hearts, ventricular grafts and cardiovascular suture.
Claims12
A device for use with blood wherein all surfaces which contact blood comprise a crosslinked polymer network comprising the reaction product of a polyethylene oxide and a glycidoxypropylsiloxane having between 3 and 25 glycidoxypropyl units per molecule.
In a device which contacts blood characterized by a need to prevent thrombus formation, the improvement which comprises providing all surfaces which contact blood with a covering comprising the reaction product of a polyethylene oxide and glycidoxypropylsiloxane having between 3 and 25 gylcidoxypropyl units per molecule.
A device for use with blood wherein all surfaces which contact blood comprise a cross-linked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane having between about 3 and 25 glycidoxypropyl units per molecule.
Dependencies are inferred from the claim text.