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US 4,906,378 AGranted
Composite chromatographic article
AssigneeMinnesota Mining and Manufacturing Company
InventorsDonald F. Hagen, Steven J. St. Mary, Louise A. Errede
Life of this patent
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Abstract
A composite chromatographic article comprising: (a) a polytetrafluoroethylene fibril matrix, and (b) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable sorptive particles to polytetrafluoroethylene being in the range of 19:1 to 4:1 by weight, said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter.
Claims32
A method of chromatographic separation comprising the steps of:
- (a) spotting a solution containing separable components in a circular configuration onto a rotatable chromatographic sheet-like article wherein said chromatographic sheet-like article is a composite article comprising:
- (1) a polytetra fluoroethylene fibril matrix, and
- (2) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable particles to PTFE being in the range of 19:1 to 4:1 by weight,
- said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter,
- (b) wicking solvent onto said chromatographic sheet-like article, just inside said spotted circular configuration, while said article is continuously rotating, to effect differential migration of said components and their separation.
2 more elements
A method of chromatographic separation comprising the steps of:
- (a) depositing a solution containing separable components in a circular configuration onto a rotatable chromatographic sheet-like article to provide a circular zone of deposited solution, wherein said chromatographic sheet-like article is a composite article comprising:
- (1) a polytetrafluoroethylene fibril matrix, and
- (2) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable particles to PTFE being in the range of 19:1 to 4:1 by weight,
- said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter,
- (b) wicking solvent onto said chromatographic sheet-like article, just inside said circular zone, while said article is continuously rotating, to effect differential migration of said components and their separation.
2 more elements
Dependencies are inferred from the claim text.