Devices and methods for preparing a solution for medicinal purposes

A device for the preparation of sterile pharmaceutical solutions for subsequent intravenous use in man or mammals, comprising:

• (a) a first bag having a flexible lining that defines a chamber, an inlet port leading to the chamber and an outlet port leading from the chamber, and a container attached to the lining of the chamber, the inlet port receiving aqueous solvent and the container containing ingredients that are releasable into the chamber, the ingredients being a solute that forms a pharmaceutical solution of known composition with the aqueous solvent;
• (b) a filtration unit having an inlet tube and an outlet tube, the inlet tube of the filtration unit being attached to the outlet port of the first bag;
• (c) a second bag having an inlet port and an outlet port, the inlet port of the second bag being attached to the outlet tube of the filtration unit, and the outlet port being attachable to an intravenous unit;
• and
• (d) an enclosure which surrounds the first bag and includes an inlet through which air is pumped to exert a positive pressure upon the chamber of the first bag to force the pharmaceutical solution from the first bag through the filtration unit and into the second bag and wherein the enclosure has hinges to open the enclosure into two halves which can be closed about the first bag, the enclosure having a gasket between the halves to provide an air-tight seal.

A device for the preparation of sterile pharmaceutical solutions for subsequent intravenous use in man or mammals, comprising:

• (a) a first bag having a flexible lining that defines a chamber, an inlet port leading to the chamber and an outlet port leading from the chamber, and a container attached to the lining of the chamber, the inlet port receiving aqueous solvent and the container containing ingredients that are releasable into the chamber, the ingredients being a solute that forms a pharmaceutical solution of known composition with the aqueous solvent;
• (b) a filtration unit having an inlet tube and an outlet tube, the inlet tube of the filtration unit being attached to the outlet port of the first bag;
• (c) a second bag having an inlet port and an outlet port, the inlet port of the second bag being attached to the outlet tube of the filtration unit, and the outlet port being attachable to an intravenous unit, wherein the second bag has a lining that defines a chamber, and a container that contains ingredients that are releasable into the second bag;
• and
• (d) means for exerting a positive pressure upon the chamber of the first bag to force the pharmaceutical solution from the first bag through the filtration unit and into the second bag.

A device for the preparation of sterile pharmaceutical solutions for subsequent intravenous use in man or mammals, comprising:

• (a) a first bag having a flexible lining that defines a chamber, an inlet port leading to the chamber and an outlet port leading from the chamber, and a container attached to the lining of the chamber, the inlet port receiving aqueous solvent and the container containing ingredients that are releasable into the chamber, the ingredients being a solute that forms a pharmaceutical solution of known composition with the aqueous solvent;
• (b) a filtration unit having an inlet tube and an outlet tube, the inlet tube of the filtration unit being attached to the outlet port of the first bag;
• (c) a second bag having an inlet port and an outlet port, the inlet port of the second bag being attached to the outlet tube of the filtration unit, and the outlet port being attachable to an intravenous unit,
• (d) means for exerting a positive pressure upon the chamber of the first bag to force the pharmaceutical solution from the first bag through the filtration unit and into the second bag;
• and
• (e) a pH meter contained within the first bag.