Preparation of tryptophols
AssigneeAmerican Home Products Corporation
InventorsBrian A. McKittrick, Alan H. Katz
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Abstract
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
Claims1
The process for producing substituted tryptophols of structure ##STR7## wherein R.sup.1 is hydrogen, lower alkyl containing 1 to 4 carbon atoms or halogen, R.sup.2 is lower alkyl containing 1 to 4 carbon atoms and X is bromine or iodine which comprises reacting the substituted isatin of structure ##STR8## wherein R.sup.1 and X are as defined above with ##STR9## wherein R.sup.2 is as defined above and R.sup.3 is methyl or ethyl, in the presence of lithium diisopropylamine and reducing the resulting product with lithium aluminum hydride.
Dependencies are inferred from the claim text.